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Science. 1989 Feb 24;243(4894 Pt 1):1066-8.

Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen.

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  • 1Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021.


Macrophage inflammatory protein-1 (MIP-1) produced a monophasic fever of rapid onset whose magnitude was equal to or greater than that of fevers produced with either recombinant human cachectin (or tumor necrosis factor) or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 was not inhibited by the cyclooxygenase inhibitor ibuprofen. Thus, MIP-1 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase inhibitors.

[PubMed - indexed for MEDLINE]
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