Novel valve replacement with an extracellular matrix scaffold in an infant with single ventricle physiology

Alvise Guariento; Redmond Burke; Marny Fedrigo; Annalisa Angelini; Nicola Maschietto; Vladimiro Vida; Gaetano Thiene; Giovanni Stellin; Massimo Padalino

doi:10.1016/j.carpath.2015.09.003

Novel valve replacement with an extracellular matrix scaffold in an infant with single ventricle physiology

Cardiovasc Pathol. 2016 Mar-Apr;25(2):165-8. doi: 10.1016/j.carpath.2015.09.003. Epub 2015 Sep 24.

Authors

Alvise Guariento¹, Redmond Burke², Marny Fedrigo³, Annalisa Angelini³, Nicola Maschietto⁴, Vladimiro Vida¹, Gaetano Thiene³, Giovanni Stellin¹, Massimo Padalino⁵

Affiliations

¹ Pediatric and Congenital Cardiac Surgery Unit, Dept of Cardiac, Thoracic and Vascular Sciences, University of Padua Via Giustiniani 2, 35100 Padua, Italy.
² Pediatric Cardiovascular Surgery Unit, Miami Children's Hospital 3100 SW 62nd Ave, Miami, FL 33155, USA).
³ Cardiovascular Pathology Unit, Dept. of Cardiac, Thoracic and Vascular Sciences, University of Padua Via Giustiniani 2, 35100 Padua, Italy.
⁴ Pediatric Cardiology Unit, Departments of Women's and Children's Health, University of Padua Via Giustiniani 2, 35100 Padua, Italy.
⁵ Pediatric and Congenital Cardiac Surgery Unit, Dept of Cardiac, Thoracic and Vascular Sciences, University of Padua Via Giustiniani 2, 35100 Padua, Italy. Electronic address: massimo.padalino@unipd.it.

PMID: 26454806
DOI: 10.1016/j.carpath.2015.09.003

Abstract

Valve replacement in children with functionally univentricular hearts remains challenging. The absence of small prostheses, the lack of growth, and the need for anticoagulation limit these procedures. We describe a 1-year follow-up of an extracellular matrix scaffold tube used as systemic atrio-ventricular valve in an infant.

Keywords: Bioengineered tissue; Congenital heart disease; Univerticular heart; Valve replacement.

Publication types

Case Reports

MeSH terms

Animals
Extracellular Matrix / metabolism
Fatal Outcome
Follow-Up Studies
Heart Valve Prosthesis Implantation / instrumentation*
Heart Valve Prosthesis Implantation / methods
Heart Ventricles / abnormalities*
Humans
Infant
Infant, Newborn
Male
Mitral Valve / surgery*
Swine
Tissue Scaffolds*