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J Cell Biol. 1989 Feb;108(2):229-41.

The scanning model for translation: an update.

Author information

  • Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260.

Abstract

The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained.

PMID:
2645293
[PubMed - indexed for MEDLINE]
PMCID:
PMC2115416
Free PMC Article
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