Human interleukin 7: molecular cloning and growth ...[Proc Natl Acad Sci U S A. 1989]

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1: Proc Natl Acad Sci U S A. 1989 Jan;86(1):302-6. Links

Human interleukin 7: molecular cloning and growth factor activity on human and murine B-lineage cells.

Goodwin RG, Lupton S, Schmierer A, Hjerrild KJ, Jerzy R, Clevenger W, Gillis S, Cosman D, Namen AE.

Immunex Corporation, Seattle, WA 98101.

A cDNA encoding biologically active human interleukin 7 was isolated by hybridization with the homologous murine clone. Nucleotide sequence analysis indicated that this cDNA was capable of encoding a protein of 177 amino acids with a signal sequence of 25 amino acids and a calculated mass of 17.4 kDa for the mature protein. Recombinant human interleukin 7 stimulated the proliferation of murine pre-B cells and was active on cells harvested from human bone marrow that are enriched for B-lineage progenitor cells. Analysis of RNA by blot hybridization demonstrated the presence of two size classes of interleukin 7 mRNA in human splenic and thymic tissue.

PMID: 2643102 [PubMed - indexed for MEDLINE]

PMCID: PMC286452

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