In this article, a rare case of large myxofibroma of the mandible has been presented. The odontogenic myxoma originated from the mesenchym ise benign and can be arised from dental papilla, dental follicle or the periodontal ligament. Myxoma is mostly located in maxilla or mandible and accompanied by an unerupted tooth and can be seen in the second or third decade of the life. It is painless and uncapsulated and the growth of tumor is slow. Since it is uncapsulated, recurrence is about 25%. Myxoma can be confused radiologically with benign or malign lesions of jaws which are radiolucent in nature. Curretting, cauterization and resection are methods of treatment and the prognosis is good.