Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4-8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X-ray diffraction.
Keywords: Cytotoxic activity; Daldinia eschscholzii; Polyketides; Radical coupling.
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