Polyketides from mantis-associated fungus Daldinia eschscholzii IFB-TL01

Chem Biodivers. 2015 Sep;12(9):1349-55. doi: 10.1002/cbdv.201400414.

Abstract

Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4-8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X-ray diffraction.

Keywords: Cytotoxic activity; Daldinia eschscholzii; Polyketides; Radical coupling.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Magnetic Resonance Spectroscopy
  • Models, Molecular
  • Polyketides / analysis*
  • Xylariales / chemistry*

Substances

  • Polyketides