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Mayo Clin Proc. 2015 Nov;90(11):1541-52. doi: 10.1016/j.mayocp.2015.08.001. Epub 2015 Sep 8.

Effects of Running on Chronic Diseases and Cardiovascular and All-Cause Mortality.

Author information

  • 1Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, School of Medicine, The University of Queensland, New Orleans, LA. Electronic address: clavie@ochsner.org.
  • 2Department of Kinesiology, College of Human Sciences, Iowa State University, Ames.
  • 3Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia.
  • 4Department of Physical Therapy and Integrative Physiology Laboratory, College of Applied Health Sciences, University of Illinois at Chicago, Chicago.
  • 5Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, MO.
  • 6Department of Preventive Medicine, Pennington Biomedical Research Center, Baton Rouge, LA.
  • 7Department of Cardiovascular Diseases, John Ochsner Heart and Vascular Institute, Ochsner Clinical School, School of Medicine, The University of Queensland, New Orleans, LA.

Abstract

Considerable evidence has established the link between high levels of physical activity (PA) and all-cause and cardiovascular disease (CVD)-specific mortality. Running is a popular form of vigorous PA that has been associated with better overall survival, but there is debate about the dose-response relationship between running and CVD and all-cause survival. In this review, we specifically reviewed studies published in PubMed since 2000 that included at least 500 runners and 5-year follow-up so as to analyze the relationship between vigorous aerobic PA, specifically running, and major health consequences, especially CVD and all-cause mortality. We also made recommendations on the optimal dose of running associated with protection against CVD and premature mortality, as well as briefly discuss the potential cardiotoxicity of a high dose of aerobic exercise, including running (eg, marathons).

Copyright © 2015 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

PMID:
26362561
[PubMed - indexed for MEDLINE]
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