Scholte wave generation during single tracking location shear wave elasticity imaging of engineered tissues

J Acoust Soc Am. 2015 Aug;138(2):EL138-44. doi: 10.1121/1.4927633.

Abstract

The physical environment of engineered tissues can influence cellular functions that are important for tissue regeneration. Thus, there is a critical need for noninvasive technologies capable of monitoring mechanical properties of engineered tissues during fabrication and development. This work investigates the feasibility of using single tracking location shear wave elasticity imaging (STL-SWEI) for quantifying the shear moduli of tissue-mimicking phantoms and engineered tissues in tissue engineering environments. Scholte surface waves were observed when STL-SWEI was performed through a fluid standoff, and confounded shear moduli estimates leading to an underestimation of moduli in regions near the fluid-tissue interface.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Cells, Cultured
  • Collagen Type I
  • Elastic Modulus
  • Elasticity Imaging Techniques / methods*
  • Feasibility Studies
  • Fibroblasts / cytology
  • Gelatin
  • Hydrogels
  • Mice
  • Oscillometry
  • Phantoms, Imaging
  • Shear Strength
  • Starch
  • Tissue Engineering*
  • Transducers, Pressure
  • Ultrasonics*
  • Water

Substances

  • Collagen Type I
  • Hydrogels
  • Water
  • Gelatin
  • Starch