Effect of remote ischemic postconditioning in inflammatory changes of the lung parenchyma of rats submitted to ischemia and reperfusion

Rev Bras Cir Cardiovasc. 2015 Jul-Sep;30(3):353-9. doi: 10.5935/1678-9741.20150005.

Abstract

Objective: To assess the effects of postconditioning remote in ischemia-reperfusion injury in rat lungs.

Methods: Wistar rats (n=24) divided into 3 groups: GA (I/R) n=8, GB (R-Po) n=8, CG (control) n=8, underwent ischemia for 30 minutes artery occlusion abdominal aorta, followed by reperfusion for 60 minutes. Resected lungs and performed histological analysis and classification of morphological findings in accordance with the degree of tissue injury. Statistical analysis of the mean rating of the degree of tissue injury.

Results: GA (3.6), GB (1.3) and CG (1.0). (GA GB X P<0.05).

Conclusion: The remote postconditioning was able to minimize the inflammatory lesion of the lung parenchyma of rats undergoing ischemia and reperfusion process.

Objetivo: Avaliar os efeitos do pós-condicionamento remoto no fenômeno de isquemia e reperfusão nos pulmões de ratos.

Métodos: Ratos Wistar (n=24) divididos em 3 grupos: GA (I/R) n=8, GB pós-condicionamento remoto n=8, GC (controle) n=8, submetidos à isquemia de 30 minutos por oclusão da artéria aorta abdominal, seguida de reperfusão de 60 minutos. Ressecados os pulmões e realizada a análise histológica e classificação dos achados morfológicos de acordo com o grau de lesão tecidual. Análise estatística das médias da classificação do grau de lesão tecidual.

Resultados: GA (3,6); GB (1,3) e GC (1,0). (GA X GB P<0,05).

Conclusão: O pós-condicionamento remoto foi capaz de minimizar a lesão inflamatória do parênquima pulmonar de ratos submetidos ao processo de isquemia e reperfusão.

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Ischemia / therapy
  • Ischemic Postconditioning / methods*
  • Lung / blood supply*
  • Lung / pathology
  • Male
  • Pneumonia / prevention & control
  • Random Allocation
  • Rats, Wistar
  • Reperfusion Injury / pathology
  • Reperfusion Injury / prevention & control*
  • Reproducibility of Results
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome