Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer's Disease in APPswe/PS1dE9 Transgenic Mice

Adv Mater. 2015 Oct 7;27(37):5499-505. doi: 10.1002/adma.201502227. Epub 2015 Aug 13.

Abstract

As nanotheranostics, Congo red/Rutin-MNPs combine the abilities of diagnosis and treatment of Alzheimer's disease (AD). The biocompatible nanotheranostics system based on iron oxide magnetic nanoparticles, with ultrasmall size and excellent magnetic properties, can specifically detect amyloid plaques by magnetic resonance imaging, realize targeted delivery of AD therapeutic agents, achieve drug controlled release by H2O2 response, and prevent oxidative stress.

Keywords: Alzheimer's disease; H2O2-responsive; magnetic resonance imaging; nanotheranostics; therapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / chemically induced
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology*
  • Amyloid beta-Protein Precursor / genetics
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Brain / drug effects
  • Brain / metabolism
  • Brain / pathology
  • Cell Line, Tumor
  • Congo Red / chemistry
  • Contrast Media* / chemistry
  • Disease Models, Animal
  • Drug Carriers* / chemistry
  • Drug Delivery Systems / methods
  • Drug Liberation
  • Ferric Compounds / chemistry
  • Humans
  • Hydrogen Peroxide / metabolism
  • Magnetic Resonance Imaging / methods
  • Magnetite Nanoparticles* / chemistry
  • Mice, Transgenic
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacokinetics
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology
  • Plaque, Amyloid / diagnosis
  • Plaque, Amyloid / metabolism
  • Plaque, Amyloid / pathology
  • Presenilin-1 / genetics
  • Presenilin-1 / metabolism
  • Rutin / administration & dosage
  • Rutin / chemistry
  • Rutin / pharmacokinetics
  • Theranostic Nanomedicine / methods*

Substances

  • APP protein, human
  • Amyloid beta-Protein Precursor
  • Contrast Media
  • Drug Carriers
  • Ferric Compounds
  • Magnetite Nanoparticles
  • Neuroprotective Agents
  • PSEN1 protein, human
  • Presenilin-1
  • ferric oxide
  • Congo Red
  • Rutin
  • Hydrogen Peroxide