Association Between Growth of Geographic Atrophy and the Complement Factor I Locus

Ophthalmic Surg Lasers Imaging Retina. 2015 Jul-Aug;46(7):772-4. doi: 10.3928/23258160-20150730-15.

Abstract

The association between the growth of geographic atrophy (GA) and a single nucleotide polymorphism (SNP) in the complement factor I (CFI) locus was investigated in the COMPLETE trial. Growth of GA at 52 weeks in eyes without the CFI at-risk allele was slightly faster than the growth in eyes with the CFI at-risk allele (P ≥ .72). The authors of the current study found that in contrast to the faster growth rate reported in CFI-positive eyes from the MAHALO trial, the CFI positive eyes in the COMPLETE trial did not grow faster, and this analysis included 24 eyes that met the MAHALO eligibility criteria.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complement C2
  • Complement C3
  • Complement Factor H / genetics
  • Complement Factor I / genetics*
  • Fluorescein Angiography
  • Genotyping Techniques
  • Geographic Atrophy / genetics*
  • Geographic Atrophy / pathology*
  • Humans
  • Polymorphism, Single Nucleotide*
  • Tomography, Optical Coherence

Substances

  • CFH protein, human
  • Complement C2
  • Complement C3
  • Complement Factor H
  • CFI protein, human
  • Complement Factor I