A New Schiff Base Chemodosimeter for Fluorescent Imaging of Ferric Ions in Living Cells

J Fluoresc. 2015 Sep;25(5):1331-7. doi: 10.1007/s10895-015-1622-1. Epub 2015 Jul 28.

Abstract

A new and efficient chemodosimeter for ferric ions has been developed. The visual and fluorescent behaviors of the compound toward various metal ions were investigated: ferric ions are distinguished from other cations by selective color change and unusual fluorescence enhancement in mixed aqueous solution. Fluorescence microscopy experiments showed that this receptor is effective for detection of Fe(3+) in vitro, developing a good image of the biological organelles. The sensing mechanism is shown to involve a hydrolysis process.

Keywords: Cell imaging; Chemodosimeter; Ferric ion detection; Fluorescence microscopy; Schiff base.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemistry
  • Animals
  • Cell Survival
  • Fluorescent Dyes / chemistry*
  • Iron / analysis*
  • Iron / chemistry*
  • Mice
  • Microscopy, Fluorescence / methods*
  • Pyrenes / chemistry
  • Quinolines / chemistry
  • RAW 264.7 Cells
  • Schiff Bases / chemistry

Substances

  • 2-quinolinecarboxaldehyde
  • Aldehydes
  • Fluorescent Dyes
  • Pyrenes
  • Quinolines
  • Schiff Bases
  • pyrene
  • Iron