Send to:

Choose Destination
See comment in PubMed Commons below
Funct Neurol. 1989 Oct-Dec;4(4):387-90.

The effects of acetyl-l-carnitine on experimental models of learning and memory deficits in the old rat.

Author information

  • 1Institute of Pharmacology, University of Catania Medical School, Italy.


Experimental models of learning and memory deficits in aged rats can be studied by means of behavioural tests that provide an important tool for evaluating the effect of drugs on these parameters. Active and passive avoidance tests showed a clear impairment of learning and memory capacity of old rats. These tests were also used to study the behavioural effect of acetyl-l-carnitine in aged rats. The subchronic treatment with this drug was followed by a significant improvement of acquisition and retention of avoidance responses, indicating a facilitation of learning and memory capacity of aged rats.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk