Deep hypothermia for the treatment of refractory status epilepticus

Epilepsy Behav. 2015 Aug:49:313-7. doi: 10.1016/j.yebeh.2015.06.028. Epub 2015 Jul 18.

Abstract

In a rat model of status epilepticus (SE) induced by lithium and pilocarpine and refractory to midazolam, deep hypothermia (20 °C for 30 min) reduced EEG power over 50-fold, stopped SE within 12 min, and reduced EEG spikes by 87%. Hypothermia deserves further investigation as a treatment of last resort for refractory SE. This article is part of a Special Issue entitled "Status Epilepticus".

Keywords: EEG power; Hypothermia; Status epilepticus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Convulsants
  • Drug Resistant Epilepsy / chemically induced
  • Drug Resistant Epilepsy / therapy*
  • Electroencephalography / drug effects
  • Hypothermia, Induced / methods*
  • Lithium
  • Male
  • Midazolam / therapeutic use
  • Pilocarpine
  • Rats
  • Rats, Wistar
  • Status Epilepticus / therapy*

Substances

  • Convulsants
  • Pilocarpine
  • Lithium
  • Midazolam