From Prescription to Transcription: Genome Sequence as Drug Target

Cong Guo; Anthony M D'Ippolito; Timothy E Reddy

doi:10.1016/j.cell.2015.06.033

From Prescription to Transcription: Genome Sequence as Drug Target

Cell. 2015 Jul 2;162(1):16-7. doi: 10.1016/j.cell.2015.06.033.

Authors

Cong Guo¹, Anthony M D'Ippolito¹, Timothy E Reddy²

Affiliations

¹ Center for Genomic and Computational Biology, Duke University Medical School, Durham, NC 27708, USA; University Program in Genetics and Genomics, Duke University Medical School, Durham, NC 27708, USA.
² Center for Genomic and Computational Biology, Duke University Medical School, Durham, NC 27708, USA; Department of Biostatistics and Bioinformatics, Duke University Medical School, Durham, NC 27708, USA. Electronic address: tim.reddy@duke.edu.

PMID: 26140587
DOI: 10.1016/j.cell.2015.06.033

Abstract

Personalizing treatments to account for genetically mediated differences in drug responses is an exciting opportunity to improve patient outcomes. In this issue, Soccio et al. reveal new mechanisms by which non-coding variants alter the activity of the anti-diabetic drug rosiglitazone.

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Comment

MeSH terms

Animals
Humans
Hypoglycemic Agents / metabolism*
PPAR gamma / genetics*
PPAR gamma / metabolism*
Polymorphism, Single Nucleotide*

Substances

Hypoglycemic Agents
PPAR gamma