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1: Forensic Sci Int. 1989 Dec;43(3):267-73.Links

Simultaneous determination of pethidine (meperidine), phenoperidine, and norpethidine (normeperidine), their common metabolite, by gas chromatography with selective nitrogen detection.

Kintz P, Godelar B, Mangin P, Lugnier AA, Chaumont AJ.

Institut de Médecine Légale, Strasbourg Cedex, France.

This article describes a selective gas chromatographic method for the resolution and quantification of phenoperidine and its two metabolites, pethidine (meperidine) and norpethidine (normeperidine). Drugs and SKF 525 A, the internal standard, are separated from plasma by solvent extraction under alkaline conditions. They are chromatographed on a 3% OV-17 Chromosorb Q glass column and detected with a nitrogen-phosphorous detector. Linearity is observed in the study range (5-200 ng/ml). No interference by endogenous substances is noted.

PMID: 2613140 [PubMed - indexed for MEDLINE]

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  • Meperidine (Demerol® Hydrochloride, Demerol® Hydrochloride Syrup)

    Meperidine is used to relieve moderate to severe pain. Meperidine is in a class of medications called narcotic analgesics, a group of pain medications similar to morphine. It works by changing the way the body senses pai...

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