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DNA Cell Biol. 2015 Sep;34(9):561-72. doi: 10.1089/dna.2015.2866. Epub 2015 Jun 23.

Curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells.

Author information

  • 11 Department of Pathology, Affiliated Hui Zhou Hospital (The Third People's Hospital of Huizhou), Guangzhou Medical University Huizhou City , Huizhou, People's Republic of China .
  • 22 Key Laboratory for Atherosclerology of Hunan Province, Institute of Cardiovascular Disease, University of South China , Hengyang, People's Republic of China .
  • 33 Department of Clinical Laboratory, Affiliated Nanhua Hospital, University of South China , Hengyang, People's Republic of China .
  • 44 Department of Ultrasonic Diagnosis, Affiliated First Hospital, Hebei Medical University , Shi Jiazhuang, People's Republic of China .

Abstract

Curcumin, a traditional Chinese derivative from the rhizomes of Curcuma longa, is beneficial to health by modulating lipid metabolism and suppressing atherogenesis. A key part of atherosclerosis is the failure of macrophages to restore their cellular cholesterol homeostasis and the formation of foam cells. In this study, results showed that curcumin dramatically increased the expression of ATP-binding cassette transporter 1 (ABCA1), promoted cholesterol efflux from THP-1 macrophage-derived foam cells, and reduced cellular cholesterol levels. Curcumin activated AMP-activated protein kinase (AMPK) and SIRT1, and then activated LXRα in THP-1 macrophage-derived foam cells. Inhibiting AMPK/SIRT1 activity by its specific inhibitor or by small interfering RNA could inhibit LXRα activation and abolish curcumin-induced ABCA1 expression and cholesterol efflux. Thus, curcumin enhanced cholesterol efflux by upregulating ABCA1 expression through activating AMPK-SIRT1-LXRα signaling in THP-1 macrophage-derived foam cells. This study describes a possible mechanism for understanding the antiatherogenic effects of curcumin on attenuating the progression of atherosclerosis.

PMID:
26102194
[PubMed - indexed for MEDLINE]
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