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J Dent. 1989 Dec;17(6):287-9.

Effects of chlorhexidine solution on neutrophil locomotion in vitro.

Abstract

The aim of this study was to ascertain the effect of low concentrations of chlorhexidine on the locomotor behaviour of neutrophils. A special feature was the use of a direct test of chemotaxis. Neutrophils recovered from peripheral blood of healthy adult volunteers were tested for chemokinesis and chemotaxis in the presence of chlorhexidine. A moderate dose-related direct response was observed in respect of both these parameters. It was also apparent that increasing concentrations of the drug inhibited a greater proportion of cells, so that there was total immobility at 0.2 per cent and many cells appeared lysed.

PMID:
2607024
[PubMed - indexed for MEDLINE]

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