Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

Marialbert Acosta-Herrera; Maria Pino-Yanes; Shwu-Fan Ma; Amalia Barreto-Luis; Almudena Corrales; José Cumplido; Eva Pérez-Rodríguez; Paloma Campo; Celeste Eng; José Carlos García-Robaina; Inés Quintela; Jesús Villar; Miguel Blanca; Ángel Carracedo; Teresa Carrillo; Joe G N Garcia; Dara G Torgerson; Esteban G Burchard; Carlos Flores

doi:10.1016/j.jaci.2015.04.025

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent

J Allergy Clin Immunol. 2015 Oct;136(4):1116-8.e9. doi: 10.1016/j.jaci.2015.04.025. Epub 2015 May 27.

Authors

Marialbert Acosta-Herrera¹, Maria Pino-Yanes², Shwu-Fan Ma³, Amalia Barreto-Luis⁴, Almudena Corrales⁴, José Cumplido⁵, Eva Pérez-Rodríguez⁶, Paloma Campo⁷, Celeste Eng⁸, José Carlos García-Robaina⁶, Inés Quintela⁹, Jesús Villar¹⁰, Miguel Blanca⁷, Ángel Carracedo¹¹, Teresa Carrillo⁵, Joe G N Garcia¹², Dara G Torgerson⁸, Esteban G Burchard¹³, Carlos Flores¹⁴

Affiliations

¹ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
² CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Department of Medicine, University of California, San Francisco, Calif.
³ Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, Ill.
⁴ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
⁵ Allergy Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
⁶ Allergy Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain.
⁷ U.G.C. Allergy, Regional University Hospital of Málaga-IBIMA, Málaga, Spain.
⁸ Department of Medicine, University of California, San Francisco, Calif.
⁹ Grupo de Medicina Xenómica, CEGEN-ISCIII-Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
¹⁰ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Multidisciplinary Organ Dysfunction Evaluation Research Network (MODERN), Research Unit, Hospital Universitario Dr. Negrin, Gran Canaria, Spain.
¹¹ Grupo de Medicina Xenómica, CIBERER-Universidade de Santiago de Compostela-Fundación Galega de Medicina Xenómica (SERGAS), Santiago de Compostela, Spain.
¹² Arizona Health Sciences Center, University of Arizona, Tucson, Ariz.
¹³ Department of Medicine, University of California, San Francisco, Calif; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, Calif.
¹⁴ CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain; Research Unit, Hospital Universitario N.S. de Candelaria, Tenerife, Spain; Applied Genomics Group (G2A), Genetics Laboratory, Instituto Universitario de Enfermedades Tropicales y Salud Pública de Canarias, Universidad de La Laguna, Tenerife, Spain. Electronic address: cflores@ull.edu.es.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Asthma / epidemiology
Asthma / genetics*
Calcium-Binding Proteins / genetics*
Chromosome Mapping / methods
Female
Humans
Male
Myosin-Light-Chain Kinase / genetics*
Polymorphism, Single Nucleotide*
Spain / epidemiology

Substances

Calcium-Binding Proteins
MYLK protein, human
Myosin-Light-Chain Kinase

Publication types

MeSH terms

Substances

Grants and funding