Reversible thermo-sensitivity induced from varying the hydrogen bonding between the side residues of rationally designed polypeptides

Hong Liu; Yan Xiao; Heng Xu; Yebin Guan; Jun Zhang; Meidong Lang

doi:10.1039/c5cc03017j

Reversible thermo-sensitivity induced from varying the hydrogen bonding between the side residues of rationally designed polypeptides

Chem Commun (Camb). 2015 Jun 25;51(50):10174-7. doi: 10.1039/c5cc03017j. Epub 2015 May 27.

Authors

Hong Liu¹, Yan Xiao, Heng Xu, Yebin Guan, Jun Zhang, Meidong Lang

Affiliation

¹ Key Laboratory of Advanced Polymeric Materials, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China. yxiao@ecust.edu.cn mdlang@ecust.edu.cn.

PMID: 26012903
DOI: 10.1039/c5cc03017j

Abstract

Rationally designed polypeptides with similar molecular structures but varying patterns of hydrogen bonding between the side groups have been synthesized and demonstrated to possess distinct solubility and thermal behaviors. Further balancing the ratio of both isopropylamine and ethylenediamine side groups endows the random copolymer with reversible thermo-sensitivity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Drug Design*
Hydrogen Bonding
Models, Molecular
Peptides / chemistry*
Protein Structure, Secondary
Solubility
Temperature*

Substances

Peptides