Investigation of curcumin release from chitosan/cellulose micro crystals (CMC) antimicrobial films

Int J Biol Macromol. 2015 Aug:79:440-8. doi: 10.1016/j.ijbiomac.2015.05.012. Epub 2015 May 21.

Abstract

Following the novel 'vapor induced phase inversion' (VIPI) method, we have prepared curcumin loaded chitosan/cellulose micro crystals composite films and characterized them by thermo gravimetric analysis (TGA), X-ray diffraction (XRD) and scanning electron microscopy (SEM). The equilibrium moisture absorption behavior of these films was investigated under different relative humidity (RH) environments and the data obtained was interpreted by the GAB isotherm model successfully. The films were also studied for their curcumin release behavior in the physiological fluid (PF) at 37 °C and the kinetic data obtained was best interpreted by Higuchi model. Finally, the films showed fair antimicrobial action against bacteria and fungi.

Keywords: Cellulose; Chitosan; Curcumin complex; Phase inversion; Wound dressings.

MeSH terms

  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Bandages
  • Candida albicans / drug effects
  • Candida albicans / growth & development
  • Cellulose / chemistry*
  • Chitosan / chemistry*
  • Crystallization
  • Curcumin / chemistry
  • Curcumin / pharmacology*
  • Disk Diffusion Antimicrobial Tests
  • Drug Liberation
  • Escherichia coli / chemistry
  • Escherichia coli / drug effects
  • Escherichia coli / growth & development
  • Humidity
  • Kinetics
  • Membranes, Artificial
  • Tensile Strength

Substances

  • Anti-Infective Agents
  • Membranes, Artificial
  • Cellulose
  • Chitosan
  • Curcumin