Abstract
The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}(6) complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents* / chemistry
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Antineoplastic Agents* / pharmacology
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Antineoplastic Agents* / radiation effects
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Catalysis
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Cell Survival / drug effects
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Coordination Complexes* / chemistry
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Coordination Complexes* / pharmacology
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Coordination Complexes* / radiation effects
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Glutathione / metabolism
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HeLa Cells
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Humans
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Hydrogen Peroxide / chemistry*
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Light
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Manganese* / chemistry
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Manganese* / pharmacology
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Manganese* / radiation effects
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Nitric Oxide / chemistry*
Substances
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Antineoplastic Agents
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Coordination Complexes
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Nitric Oxide
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Manganese
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Hydrogen Peroxide
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Glutathione