Uncaging a catalytic hydrogen peroxide generator through the photo-induced release of nitric oxide from a {MnNO}(6) complex

Chem Commun (Camb). 2015 Jun 11;51(46):9539-42. doi: 10.1039/c5cc02566d.

Abstract

The photo-initiated cytotoxicity of a newly developed manganese nitrosyl {MnNO}(6) complex (UG1NO) to HeLa cells is described. The complex was found to be strongly cytotoxic after being exposed to light with a wavelength of 650 nm. Cell death was caused by a manganese(II) complex, UG1, generated from UG1NO through the photo-dissociation of NO, rather than by NO directly. Mechanistic studies revealed that UG1 consumes O2 only in the presence of a reducing agent to catalytically produce H2O2.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents* / chemistry
  • Antineoplastic Agents* / pharmacology
  • Antineoplastic Agents* / radiation effects
  • Catalysis
  • Cell Survival / drug effects
  • Coordination Complexes* / chemistry
  • Coordination Complexes* / pharmacology
  • Coordination Complexes* / radiation effects
  • Glutathione / metabolism
  • HeLa Cells
  • Humans
  • Hydrogen Peroxide / chemistry*
  • Light
  • Manganese* / chemistry
  • Manganese* / pharmacology
  • Manganese* / radiation effects
  • Nitric Oxide / chemistry*

Substances

  • Antineoplastic Agents
  • Coordination Complexes
  • Nitric Oxide
  • Manganese
  • Hydrogen Peroxide
  • Glutathione