The purpose of this study was to examine whether tu-mor necrosis factor-α (TNF-α) -308 A/G and -238 A/G polymorphisms confer susceptibility to glaucoma. A meta-analysis was conducted ex-amining the association between TNF-α -308 A/G and -238 A/G poly-morphisms and glaucoma. A total of 13 studies on TNF-α -308 A/G and 238 A/G polymorphisms were included in this meta-analysis. The meta-analysis revealed no association between the TNF-α -308 A al-lele and glaucoma [odds ratio (OR) = 1.403, 95% confidence inter-val (CI) = 0.784-2.513, P = 0.254]. Subgroup analysis by disease type revealed no association between the TNF-α -308 A allele and glau-coma. The meta-analysis revealed no significant association between the TNF-α -238 A allele and glaucoma (OR = 1.120, 95%CI = 0.708-1.773, P = 0.628). This meta-analysis showed no association between the A alleles of the TNF-α -308 A/G or -238 A/G polymorphisms and glaucoma.