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Molecular cloning and chromosomal assignment of a human perforin (PFP) gene.
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
Human perforin cDNA was isolated and the complete nucleotide sequence of the gene determined. The deduced amino acid sequence of human perforin showed 68.4% similarity to that of mouse perforin. RNA blot analysis of the human perforin gene revealed that the gene product is expressed preferentially in killer-type cells among cell lines tested, and in large granular lymphocytes among the peripheral blood mononuclear cells. In situ hybridization analysis with a human perforin cDNA probe revealed that the human perforin (PFP) gene is located on chromosome 17q11-21.
PMID: 2592021 [PubMed - indexed for MEDLINE]
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Cited by 10 PubMed Central articles
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Spectrum of perforin gene mutations in familial hemophagocytic lymphohistiocytosis.
Göransdotter Ericson K, Fadeel B, Nilsson-Ardnor S, Söderhäll C, Samuelsson A, Janka G, Schneider M, Gürgey A, Yalman N, Révész T, et al.
Am J Hum Genet. 2001 Mar; 68(3):590-7. Epub 2001 Feb 6.
[Am J Hum Genet. 2001]
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Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE.
Perera LP, Waldmann TA.
Proc Natl Acad Sci U S A. 1998 Nov 24; 95(24):14308-13.
[Proc Natl Acad Sci U S A. 1998]
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Identification of an astrocyte cell population from human brain that expresses perforin, a cytotoxic protein implicated in immune defense.
Gasque P, Jones J, Singhrao SK, Morgan B.
J Exp Med. 1998 Feb 16; 187(4):451-60.
[J Exp Med. 1998]
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