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    Immunogenetics. 1989;30(6):452-7.

    Molecular cloning and chromosomal assignment of a human perforin (PFP) gene.

    Shinkai Y, Yoshida MC, Maeda K, Kobata T, Maruyama K, Yodoi J, Yagita H, Okumura K.

    Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.

    Human perforin cDNA was isolated and the complete nucleotide sequence of the gene determined. The deduced amino acid sequence of human perforin showed 68.4% similarity to that of mouse perforin. RNA blot analysis of the human perforin gene revealed that the gene product is expressed preferentially in killer-type cells among cell lines tested, and in large granular lymphocytes among the peripheral blood mononuclear cells. In situ hybridization analysis with a human perforin cDNA probe revealed that the human perforin (PFP) gene is located on chromosome 17q11-21.

    PMID: 2592021 [PubMed - indexed for MEDLINE]

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