Genomics. 1989 Nov;5(4):940-4.

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.

Gilliam TC, Freimer NB, Kaufmann CA, Powchik PP, Bassett AS, Bengtsson U, Wasmuth JJ.

Source

Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York 10032.

Abstract

Two independent lines of evidence support the localization of a schizophrenia susceptibility locus to the proximal long arm of chromosome 5. A partial trisomy of chromosome 5 (5q11.2-q13.3) cosegregates with the disorder in a Canadian family of Chinese descent, and DNA markers from proximal 5q cosegregate with schizophrenia (plus related disorders) in families of British and Icelandic descent. We constructed a human:hamster hybrid cell line (HHW 1064) whose only human complement is a chromosome 5 that is missing the trisomic region associated with schizophrenia. In combination with a "matched" cell hybrid (HHW 105) containing an intact chromosome 5, we physically mapped DNA markers relative to the trisomy. "Schizophrenia-linked" DNA markers p105-153Ra (D5S39) and p105-599Ha (D5S76) map within the trisomy and proximal to the 5q11.2 breakpoint, respectively. The hybrid cell lines HHW 105 and HHW 1064 together provide a means to identify and generate syntenic DNA markers to further investigate the location of a schizophrenia locus.

PMID:: 2591972; [PubMed - indexed for MEDLINE]
PMCID:: PMC3154173

Free PMC Article

Images from this publication.See all images (3)Free text

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

PubReader: Say goodbye to the old way of reading articles.

Related citations in PubMed

Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q. [Schizophr Bull. 1989]
Physical mapping, linkage analysis of a putative schizophrenia locus on chromosome 5q.
Kaufmann CA, DeLisi LE, Lehner T, Gilliam TC. Schizophr Bull. 1989; 15(3):441-52.
No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families. [Nature. 1989]
No linkage of chromosome 5q11-q13 markers to schizophrenia in Scottish families.
St Clair D, Blackwood D, Muir W, Baillie D, Hubbard A, Wright A, Evans HJ. Nature. 1989 May 25; 339(6222):305-9.
New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families. [Ann Hum Genet. 1999]
New DNA markers with increased informativeness show diminished support for a chromosome 5q11-13 schizophrenia susceptibility locus and exclude linkage in two new cohorts of British and Icelandic families.
Kalsi G, Mankoo B, Curtis D, Sherrington R, Melmer G, Brynjolfsson J, Sigmundsson T, Read T, Murphy P, Petursson H, et al. Ann Hum Genet. 1999 May; 63(Pt 3):235-47.
Review [Identification of the breakpoint-flanking markers on chromosomes 1 and 17 of a constitutional translocation T(1;17)(P36;Q12-21) in a patient with neuroblastoma]. [Verh K Acad Geneeskd Belg. 1995]
Review [Identification of the breakpoint-flanking markers on chromosomes 1 and 17 of a constitutional translocation T(1;17)(P36;Q12-21) in a patient with neuroblastoma].
Laureys GG. Verh K Acad Geneeskd Belg. 1995; 57(5):389-422.
Review A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11. [Psychol Med. 1993]
Review A linkage study of schizophrenia with DNA markers from the long arm of chromosome 11.
Gill M, McGuffin P, Parfitt E, Mant R, Asherson P, Collier D, Vallada H, Powell J, Shaikh S, Taylor C. Psychol Med. 1993 Feb; 23(1):27-44.

See reviews... See all...

Cited by 10 PubMed Central articles

Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism. [Am J Hum Genet. 2001]
Genetics of event-related brain potentials in response to a semantic priming paradigm in families with a history of alcoholism.
Almasy L, Porjesz B, Blangero J, Goate A, Edenberg HJ, Chorlian DB, Kuperman S, O'Connor SJ, Rohrbaugh J, Bauer LO, et al. Am J Hum Genet. 2001 Jan; 68(1):128-135. Epub 2000 Dec 1.
Cosegregation of schizophrenia with Becker muscular dystrophy: susceptibility locus for schizophrenia at Xp21 or an effect of the dystrophin gene in the brain? [J Med Genet. 1993]
Cosegregation of schizophrenia with Becker muscular dystrophy: susceptibility locus for schizophrenia at Xp21 or an effect of the dystrophin gene in the brain?
Zatz M, Vallada H, Melo MS, Passos-Bueno MR, Vieira AH, Vainzof M, Gill M, Gentil V. J Med Genet. 1993 Feb; 30(2):131-4.
Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region. [Proc Natl Acad Sci U S A. 1993]
Construction of a yeast artificial chromosome contig spanning the spinal muscular atrophy disease gene region.
Kleyn PW, Wang CH, Lien LL, Vitale E, Pan J, Ross BM, Grunn A, Palmer DA, Warburton D, Brzustowicz LM. Proc Natl Acad Sci U S A. 1993 Jul 15; 90(14):6801-5.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
UniSTS
Genetic, physical, and sequence mapping reagents in the UniSTS database associated with the current articles through references on sequence tagged site (STS) submissions as well as automated searching of PubMed abstracts and full-text PubMed Central articles for marker names.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates wi...
Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.
Genomics. 1989 Nov ;5(4):940-4.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Deletion mapping of DNA markers to a region of chromosome 5 that cosegregates with schizophrenia.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information