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Alzheimers Dement. 2015 Nov;11(11):1349-57. doi: 10.1016/j.jalz.2014.12.007. Epub 2015 Apr 24.

Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset.

Author information

  • 1Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, National Hospital for Neurology and Neurosurgery, London, UK. Electronic address: j.barnes@ucl.ac.uk.
  • 2Department of Neurology, Frontotemporal Dementia Unit and Alzheimer's Disease Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • 3Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
  • 4Department of Neurology, Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; Department of Neurology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • 5Department of Neurology, Penn Memory Center, University of Pennsylvania, Philadelphia, PA, USA.
  • 6Department of Neurology, Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands; Department of Epidemiology & Biostatistics, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.

Abstract

INTRODUCTION:

Determining the relationship between age and Alzheimer's disease (AD) presentation is important to improve understanding and provide better patient services.

METHODS:

We used AD patient data (N = 7815) from the National Alzheimer Coordinating Center database and multinomial logistic regression to investigate presentation age and first cognitive/behavioral symptoms.

RESULTS:

The odds of having a nonmemory first cognitive symptom (including impairment in judgment and problem solving, language, and visuospatial function) increased with younger age (P < .001, all tests). Compared with apathy/withdrawal, the odds of having depression and "other" behavioral symptoms increased with younger age (P < .02, both tests), whereas the odds of having psychosis and no behavioral symptom increased with older age (P < .001, both tests).

DISCUSSION:

There is considerable heterogeneity in the first cognitive/behavioral symptoms experienced by AD patients. Proportions of these symptoms change with age with patients experiencing increasing nonmemory cognitive symptoms and more behavioral symptoms at younger ages.

Copyright © 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

KEYWORDS:

Age; Alzheimer's disease; Behavior; Clinical neurology history; Cognition; First symptoms; Neuropsychology

PMID:
25916562
[PubMed - in process]
PMCID:
PMC4619185
[Available on 2016-11-01]
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