Abstract
In this issue of Blood, Magwenzi et al from the University of Hull report a novel mechanistic connection between oxidized low-density lipoprotein (oxLDL)-induced prothrombotic platelet signaling and the inhibition of endogenous platelet anti-activating signaling mediated by the nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway.
MeSH terms
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Animals
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Blood Platelets / cytology*
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CD36 Antigens / metabolism*
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Cyclic GMP-Dependent Protein Kinases / metabolism*
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Humans
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Lipoproteins, LDL / metabolism*
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Membrane Glycoproteins / metabolism*
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NADPH Oxidases / metabolism*
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Signal Transduction*
Substances
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CD36 Antigens
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Lipoproteins, LDL
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Membrane Glycoproteins
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NADPH Oxidases
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Cyclic GMP-Dependent Protein Kinases