Disabling the platelet's brakes to promote thrombosis

Blood. 2015 Apr 23;125(17):2591-3. doi: 10.1182/blood-2015-03-630822.

Abstract

In this issue of Blood, Magwenzi et al from the University of Hull report a novel mechanistic connection between oxidized low-density lipoprotein (oxLDL)-induced prothrombotic platelet signaling and the inhibition of endogenous platelet anti-activating signaling mediated by the nitric oxide (NO)/guanosine 3′,5′-cyclic monophosphate (cGMP)/protein kinase G (PKG) pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • Blood Platelets / cytology*
  • CD36 Antigens / metabolism*
  • Cyclic GMP-Dependent Protein Kinases / metabolism*
  • Humans
  • Lipoproteins, LDL / metabolism*
  • Membrane Glycoproteins / metabolism*
  • NADPH Oxidases / metabolism*
  • Signal Transduction*

Substances

  • CD36 Antigens
  • Lipoproteins, LDL
  • Membrane Glycoproteins
  • NADPH Oxidases
  • Cyclic GMP-Dependent Protein Kinases