Crohn's Disease With Ovarian Granuloma: A Case Report and Review of the Literature

J Minim Invasive Gynecol. 2015 Jul-Aug;22(5):914-6. doi: 10.1016/j.jmig.2015.04.010. Epub 2015 Apr 20.

Abstract

We present an interesting case of a 35-year-old nulligravida with Crohn's disease with ovarian involvement. This is a rare manifestation of Crohn's disease, felt to arise from fistulization between the ovary and the intestine, most commonly the ileum. Our review of the literature revealed 11 additional case reports published in English with a total of 15 cases. The mean age at time of presentation was 33.7 years, with a predominance of right-sided involvement. This series included 10 patients with affected right ovaries, 3 with affected left ovaries, and 2 with bilateral involvement. We conclude that ovarian involvement in Crohn's disease, although rare, can exist, and that the gynecologic surgeon should be aware of this relevant disease manifestation.

Keywords: Crohn's disease; Ileo-ovarian fistula; Ovarian granuloma; Ovarian vegetable foreign matter; Pelvic pain.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Crohn Disease / complications
  • Crohn Disease / pathology*
  • Crohn Disease / surgery
  • Estrogens / administration & dosage
  • Estrogens, Conjugated (USP) / administration & dosage
  • Female
  • Granuloma / complications
  • Granuloma / pathology*
  • Granuloma / surgery
  • Humans
  • Hysterectomy*
  • Ovary / pathology*
  • Pelvic Pain / etiology
  • Pelvic Pain / surgery*
  • Salpingectomy*
  • Treatment Outcome

Substances

  • Estrogens
  • Estrogens, Conjugated (USP)