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Structural analysis of the gene for human acidic fibroblast growth factor.
California Biotechnology Inc., Mountain View 94043.
Genomic clones derived from the gene for human acidic fibroblast growth factor (aFGF) have been isolated. Nucleotide sequence analysis of these clones revealed that the coding region of the human aFGF gene is interrupted by two introns, located at precisely homologous locations to introns in four other members of the FGF gene family, strongly indicating a common evolutionary origin for these genes. Northern blot analyses of the multiple aFGF transcripts found in serum-stimulated human foreskin fibroblasts indicated that the aFGF gene also contains a third intron, lying in the 5' untranslated region.
PMID: 2590193 [PubMed - indexed for MEDLINE]
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Cited by 4 PubMed Central articles
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Cloning of an intracellular protein that binds selectively to mitogenic acidic fibroblast growth factor.
Kolpakova E, Wiedłocha A, Stenmark H, Klingenberg O, Falnes PO, Olsnes S.
Biochem J. 1998 Nov 15; 336 ( Pt 1):213-22.
[Biochem J. 1998]
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Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development.
Smallwood PM, Munoz-Sanjuan I, Tong P, Macke JP, Hendry SH, Gilbert DJ, Copeland NG, Jenkins NA, Nathans J.
Proc Natl Acad Sci U S A. 1996 Sep 3; 93(18):9850-7.
[Proc Natl Acad Sci U S A. 1996]
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A sequence tagged site (STS) detects EcoRI polymorphisms in the human acidic fibroblast growth factor gene.
Wang WP, Chiu IM.
Nucleic Acids Res. 1991 Aug 25; 19(16):4563.
[Nucleic Acids Res. 1991]
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