Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?

A Schoenfeld; S Freedman; M Hod; Y Ovadia

doi:10.1016/0002-9378(89)90666-2

Antagonism of antihypertensive drug therapy in pregnancy by indomethacin?

Am J Obstet Gynecol. 1989 Nov;161(5):1204-5. doi: 10.1016/0002-9378(89)90666-2.

Authors

A Schoenfeld¹, S Freedman, M Hod, Y Ovadia

Affiliation

¹ Department of Obstetric and Gynecology, Beilins on Medical Center, Tel Aviv University Medical School, Petah Tikva, Israel.

PMID: 2589441
DOI: 10.1016/0002-9378(89)90666-2

Abstract

Two women with preeclampsia treated with pindolol and propranolol became profoundly hypertensive when indomethacin was added because of premature contractions. The interaction of nonsteroidal antiinflammatory agents and beta-blockers and their role in the control of blood pressure in obstetrics are discussed. Indomethacin should not be given to pregnant patients with hypertension treated with beta-blockers.

Publication types

Case Reports

MeSH terms

Adult
Antihypertensive Agents / antagonists & inhibitors*
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects
Female
Humans
Indomethacin / adverse effects*
Indomethacin / therapeutic use
Obstetric Labor, Premature / drug therapy*
Pindolol / antagonists & inhibitors
Pindolol / therapeutic use
Pre-Eclampsia / drug therapy*
Pre-Eclampsia / physiopathology
Pregnancy
Propranolol / antagonists & inhibitors
Propranolol / therapeutic use

Substances

Antihypertensive Agents
Propranolol
Pindolol
Indomethacin