Overwhelming postsplenectomy infection

Genet Mol Res. 2015 Mar 30;14(1):2702-6. doi: 10.4238/2015.March.30.30.

Abstract

This report aims to deepen the understanding of the pathogenesis, diagnosis, clinical characteristics, and treatment of overwhelming postsplenectomy infection (OPSI). A patient treated at Taihe Hospital for tuberculous OPSI is described, and relevant literature is reviewed. Broad-spectrum antibiotics, suppression of the systemic inflammatory reaction, and anti-shock measures were the keys to the successful treatment of this condition. OPSI is a life-threatening condition and has a high mortality rate. Early diagnosis, use of anti-inflammatory glucocorticoids, and administration of high-dose gamma globulin and ulinastatin for the treatment of OPSI may improve outcomes.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenal Gland Diseases / diagnosis
  • Adrenal Gland Diseases / etiology
  • Adrenal Glands / blood supply
  • Adult
  • Diagnosis, Differential
  • Hemorrhage / diagnosis
  • Hemorrhage / etiology
  • Humans
  • Infections / diagnosis*
  • Infections / etiology
  • Infections / therapy
  • Male
  • Postoperative Complications / diagnosis*
  • Postoperative Complications / etiology
  • Postoperative Complications / therapy
  • Splenectomy / adverse effects*
  • Tuberculosis / diagnosis*
  • Tuberculosis / etiology