Release of cardiac troponin using a high sensitivity assay after exercise: Type 2 acute myocardial infarction?

Clin Chim Acta. 2015 Jun 15:446:6-8. doi: 10.1016/j.cca.2015.04.002. Epub 2015 Apr 8.

Abstract

Background: Cardiac troponin is used as a marker for all types of myocardial infarction.

Methods: Assays for high-sensitivity troponin T and I were performed before, immediately and 24h after a 40 km bicycle ride in two middle aged individuals.

Results: There was a significant increase in cardiac troponin immediately after exercise in both individuals. This was accompanied by a return to baseline levels within 24h. A CT angiogram was normal in one while the other had a significant occlusion in the mid-right coronary artery. After a stent placement, in this latter individual, there was no major increase in troponin after a second bicycle ride.

Conclusions: Using high sensitivity assays, at least one of these two subjects may have suffered a type 2 myocardial infarction had the increases in hs-cTnI were accompanied by other acceptable evidence of myocardial ischemia (symptoms, ECG, etc.).

Keywords: CT angiogram; Cardiac troponin; High sensitivity; Type 2 myocardial infarction.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers / blood
  • Exercise / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / blood*
  • Myocardial Infarction / diagnostic imaging*
  • Radiography
  • Troponin I / blood*
  • Troponin T / blood*

Substances

  • Biomarkers
  • Troponin I
  • Troponin T