Immunoengineering: how nanotechnology can enhance cancer immunotherapy

Cell. 2015 Apr 9;161(2):201-4. doi: 10.1016/j.cell.2015.03.037.

Abstract

Although cancer immunotherapy can lead to durable outcomes, the percentage of patients who respond to this disruptive approach remains modest to date. Encouragingly, nanotechnology can enhance the efficacy of immunostimulatory small molecules and biologics by altering their co-localization, biodistribution, and release kinetics.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cancer Vaccines / therapeutic use*
  • Dendritic Cells / immunology
  • Humans
  • Immunotherapy*
  • Nanotechnology*
  • Neoplasms / immunology*
  • Neoplasms / therapy*
  • T-Lymphocytes / immunology

Substances

  • Cancer Vaccines