Clinicopathologic features of 112 cases with mantle cell lymphoma

Dong-Mei Zhou; Gang Chen; Xiong-Wei Zheng; Wei-Feng Zhu; Bao-Zhen Chen

doi:10.7497/j.issn.2095-3941.2015.0007

Clinicopathologic features of 112 cases with mantle cell lymphoma

Cancer Biol Med. 2015 Mar;12(1):46-52. doi: 10.7497/j.issn.2095-3941.2015.0007.

Authors

Dong-Mei Zhou¹, Gang Chen¹, Xiong-Wei Zheng¹, Wei-Feng Zhu¹, Bao-Zhen Chen¹

Affiliation

¹ Department of Pathology, Key Laboratory of Cancer Translational Medicine of Fujian, Teaching Hospital of Fujian Medical University, Fujian Tumor Hospital, Fuzhou 350014, China.

Abstract

Objective: This study aims to explore the clinicopathologic features of 112 patients with mantle cell lymphoma (MCL).

Methods: Data from 112 MCL cases were collected, and immunohistochemical assay was conducted. Fluorescence in situ hybridization (FISH) detected a break in the CCND1 gene. The t-test was used in the statistical analysis.

Results: All tumor cells in the 112 cases expressed B cell-related antigen, including 1 blastoid subtype and 1 polymorphic subtype. Among all cases, 106 expressed CD5 and 104 expressed cyclin D1. A break in the CCND1 gene was not found in 3 cases with CD5-MCL. IgH/CCND1 polyploid was observed in 2 classic cases.

Conclusion: MCL is a type of special immunophenotypic B-cell lymphoma. The prognoses of blastoid and polymorphic subtypes are poor. Special subtypes should be classified during diagnosis.

Keywords: Mantle cell lymphoma (MCL); fluorescence in situ hybridization (FISH); immunohistochemistry; prognosis.