Serum IgG and IgA levels in polio and non-polio acute flaccid paralysis cases in western Uttar Pradesh, India

Indian Pediatr. 2015 Mar 8;52(3):220-2. doi: 10.1007/s13312-015-0610-5.

Abstract

Objective: IgG and IgA immunocompetence of children with wild poliovirus poliomyelitis and non-polio acute flaccid paralysis.

Methods: 932 cases of acute flaccid paralysis, reported in 2008-2009, were tested for presence of polio and non-polio enteroviruses according to the WHO standards. Serum IgA and IgG levels were determined by sandwich ELISA.

Results: Mean (SD) IgA levels [0.87 (0.62)g/L; n=28] of virologically confirmed poliomyelitis cases were lower than those of virus negative [1.21 (0.83)g/L; n=612] and non-polio Enterovirus positive [1.22 (0.79)g/L; n=240] cases of acute flaccid paralysis. No significant difference was observed in the concentration of IgG among these groups.

Conclusions: IgA plays an important role in protection against poliomyelitis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Feces / virology
  • Humans
  • Immunoglobulin A / blood*
  • Immunoglobulin G / blood*
  • India / epidemiology
  • Infant
  • Infant, Newborn
  • Paraplegia / epidemiology*
  • Paraplegia / immunology*
  • Poliomyelitis / epidemiology*
  • Poliomyelitis / immunology*
  • Poliovirus / immunology
  • Seroepidemiologic Studies

Substances

  • Immunoglobulin A
  • Immunoglobulin G