Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2073-82. doi: 10.1073/pnas.1423936112. Epub 2015 Apr 6.

Asphyxia-activated corticocardiac signaling accelerates onset of cardiac arrest.

Author information

  • 1Departments of Molecular and Integrative Physiology.
  • 2Chemistry, Pharmacology.
  • 3Chemistry.
  • 4Departments of Molecular and Integrative Physiology, Neurology, and Neuroscience Graduate Program, Cardiovascular Center, and Veterans Administration Ann Arbor Healthcare System, Ann Arbor, MI 48105.
  • 5Cardiovascular Center, and Internal Medicine-Cardiology, Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109; and.
  • 6Departments of Molecular and Integrative Physiology, Neurology, and Neuroscience Graduate Program, Cardiovascular Center, and Michigan Center for Integrative Research in Critical Care, University of Michigan, Ann Arbor, MI 48109; and borjigin@umich.edu.

Abstract

The mechanism by which the healthy heart and brain die rapidly in the absence of oxygen is not well understood. We performed continuous electrocardiography and electroencephalography in rats undergoing experimental asphyxia and analyzed cortical release of core neurotransmitters, changes in brain and heart electrical activity, and brain-heart connectivity. Asphyxia stimulates a robust and sustained increase of functional and effective cortical connectivity, an immediate increase in cortical release of a large set of neurotransmitters, and a delayed activation of corticocardiac functional and effective connectivity that persists until the onset of ventricular fibrillation. Blocking the brain's autonomic outflow significantly delayed terminal ventricular fibrillation and lengthened the duration of detectable cortical activities despite the continued absence of oxygen. These results demonstrate that asphyxia activates a brainstorm, which accelerates premature death of the heart and the brain.

KEYWORDS:

asphyxic cardiac arrest; autonomic nervous system; coherence; directed connectivity; near-death experience

PMID:
25848007
[PubMed - indexed for MEDLINE]
PMCID:
PMC4413312
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk