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Br J Cancer. 2015 Mar 31;112(7):1247-50. doi: 10.1038/bjc.2015.26.

Muscle-building supplement use and increased risk of testicular germ cell cancer in men from Connecticut and Massachusetts.

Author information

  • 11] Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, LEPH 440, New Haven, CT 06520-8034, USA [2] National Office for Cancer Prevention and Control, China Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
  • 2Department of Environmental Health Sciences, Harvard School of Public Health, Boston, MA 02115, USA.
  • 3Department of Environmental Health Sciences, Yale School of Public Health, 60 College Street, LEPH 440, New Haven, CT 06520-8034, USA.
  • 4Department of Urology, Yale School of Medicine, New Haven, CT 06510, USA.
  • 5Fred Hutchinson Cancer Research Center, Seattle, WA 19024, USA.
  • 6International Prevention and Research Institute, Lyon 69006, France.
  • 7National Office for Cancer Prevention and Control, China Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
  • 8Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
  • 9Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA.

Abstract

BACKGROUND:

No analytic epidemiological study has examined the relationship between use of muscle-building supplements (MBSs) and testicular germ cell cancer (TGCC) risk.

METHODS:

We conducted a population-based case-control study including 356 TGCC cases and 513 controls from Connecticut and Massachusetts.

RESULTS:

The odds ratio (OR) for ever use of MBSs in relation to risk of TGCC was significantly elevated (OR=1.65, 95% confidence interval (CI): 1.11-2.46). The associations were significantly stronger among early users, men with more types of MBSs used, and longer periods of use.

CONCLUSIONS:

MBS use is a potentially modifiable risk factor that may be associated with TGCC.

PMID:
25826226
[PubMed - indexed for MEDLINE]
PMCID:
PMC4385953
Free PMC Article
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