Steroid-Induced Osteonecrosis in Dermatology: A Review

J Cutan Med Surg. 2015 Jul-Aug;19(4):358-60. doi: 10.1177/1203475415579759. Epub 2015 Mar 30.

Abstract

Background: Steroid-induced osteonecrosis is unpredictable and highly morbid.

Methods: MEDLINE (Ovid) and PubMed search for relevant literature.

Results: Oral steroid doses typically considered to be associated with the condition are >20 mg of prednisone (or equivalent) per day or >2 g within a period of 2 to 3 months. Symptoms may be vague.

Conclusions: Dermatologists must exercise a high degree of clinical suspicion and warn patients about steroid-related risks and conditions for follow-up.

Keywords: aseptic necrosis; avascular necrosis; bone death; corticosteroids; dermatology; glucocorticosteroids; ischemic necrosis; osteochondritis dissecans; osteonecrosis; steroids.

Publication types

  • Review

MeSH terms

  • Humans
  • Osteonecrosis / chemically induced*
  • Risk Factors
  • Steroids / administration & dosage
  • Steroids / adverse effects*

Substances

  • Steroids