Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics

Xueting Li; Min Xue; Otto G Raabe; Holly L Aaron; Ellen A Eisen; James E Evans; Fred A Hayes; Sumire Inaga; Abderrahmane Tagmount; Minoru Takeuchi; Chris Vulpe; Jeffrey I Zink; Subhash H Risbud; Kent E Pinkerton

doi:10.1016/j.nano.2015.03.007

Aerosol droplet delivery of mesoporous silica nanoparticles: A strategy for respiratory-based therapeutics

Nanomedicine. 2015 Aug;11(6):1377-85. doi: 10.1016/j.nano.2015.03.007. Epub 2015 Mar 25.

Authors

Xueting Li¹, Min Xue², Otto G Raabe³, Holly L Aaron⁴, Ellen A Eisen⁵, James E Evans⁶, Fred A Hayes⁷, Sumire Inaga⁸, Abderrahmane Tagmount⁹, Minoru Takeuchi¹⁰, Chris Vulpe¹¹, Jeffrey I Zink¹², Subhash H Risbud¹³, Kent E Pinkerton¹⁴

Affiliations

¹ Center for Health and the Environment, University of California, Davis, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA; Department of Chemical Engineering and Materials Science, University of California, Davis, USA. Electronic address: xl2479@columbia.edu.
² Department of Chemistry and Biochemistry, University of California, Los Angeles, USA. Electronic address: mxue@chem.ucla.edu.
³ Center for Health and the Environment, University of California, Davis, USA; Department of Molecular Biosciences, University of California, Davis, USA. Electronic address: ograabe@ucdavis.edu.
⁴ Cancer Research Laboratory Molecular Imaging Center, University of California, Berkeley, USA. Electronic address: hollya@berkeley.edu.
⁵ Environmental Health Sciences, School of Public Health, University of California, Berkeley, USA. Electronic address: eeisen@berkeley.edu.
⁶ Center for Health and the Environment, University of California, Davis, USA. Electronic address: james.evans@pnnl.gov.
⁷ Department of Chemical Engineering and Materials Science, University of California, Davis, USA. Electronic address: fahayes@ucdavis.edu.
⁸ Department of Functional, Morphological and Regulatory Science, Tottori University, Yonago, Japan. Electronic address: sumire@med.tottori-u.ac.jp.
⁹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA. Electronic address: tagmount@berkeley.edu.
¹⁰ Department of Animal Medical Science, Kyoto Sangyo University, Kyoto, Japan. Electronic address: mtakex@cc.kyoto-su.ac.jp.
¹¹ Department of Nutritional Sciences and Toxicology, University of California, Berkeley, USA. Electronic address: vulpe@berkeley.edu.
¹² Department of Chemistry and Biochemistry, University of California, Los Angeles, USA. Electronic address: Zink@chem.ucla.edu.
¹³ Department of Chemical Engineering and Materials Science, University of California, Davis, USA. Electronic address: shrisbud@ucdavis.edu.
¹⁴ Center for Health and the Environment, University of California, Davis, USA. Electronic address: kepinkerton@ucdavis.edu.

Abstract

A highly versatile nanoplatform that couples mesoporous silica nanoparticles (MSNs) with an aerosol technology to achieve direct nanoscale delivery to the respiratory tract is described. This novel method can deposit MSN nanoparticles throughout the entire respiratory tract, including nasal, tracheobronchial and pulmonary regions using a water-based aerosol. This delivery method was successfully tested in mice by inhalation. The MSN nanoparticles used have the potential for carrying and delivering therapeutic agents to highly specific target sites of the respiratory tract. The approach provides a critical foundation for developing therapeutic treatment protocols for a wide range of diseases where aerosol delivery to the respiratory system would be desirable.

From the clinical editor: Delivery of drugs via the respiratory tract is an attractive route of administration. In this article, the authors described the design of mesoporous silica nanoparticles which could act as carriers for drugs. The underlying efficacy was successfully tested in a mouse model. This drug-carrier inhalation nanotechnology should potentially be useful in human clinical setting in the future.

Keywords: Aerosol droplets; Mesoporous silica nanoparticles; Respiratory tract.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Administration, Inhalation
Aerosols*
Animals
Bronchoalveolar Lavage Fluid
Lung Diseases / therapy
Male
Mice
Microscopy, Electron, Transmission
Nanoparticles*
Silicon Dioxide / administration & dosage*
Silicon Dioxide / therapeutic use

Substances

Aerosols
Silicon Dioxide

Abstract

Publication types

MeSH terms

Substances

Grants and funding