Dactylomelane diterpenes from the sea hare Aplysia depilans

Anastasia Petraki; Efstathia Ioannou; Panagiota Papazafiri; Vassilios Roussis

doi:10.1021/np500851w

Dactylomelane diterpenes from the sea hare Aplysia depilans

J Nat Prod. 2015 Mar 27;78(3):462-7. doi: 10.1021/np500851w. Epub 2015 Jan 20.

Authors

Anastasia Petraki¹, Efstathia Ioannou¹, Panagiota Papazafiri², Vassilios Roussis¹

Affiliations

¹ †Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
² ‡Department of Animal and Human Physiology, Faculty of Biology, School of Science, University of Athens, Panepistimiopolis Zografou, Athens 15784, Greece.

PMID: 25814031
DOI: 10.1021/np500851w

Abstract

A chemical investigation of the organic extract of the sea hare Aplysia depilans, collected off Skyros Island, Greece, yielded eight new brominated diterpenes (1-8), featuring the rare dactylomelane skeleton, together with the previously reported luzodiol (9). The structure elucidation and the assignment of the relative configurations of the new natural products were based on extensive NMR spectroscopic and MS spectrometric analyses. Compounds 1-9 were evaluated for their cytotoxic activities against five human tumor cell lines, but were proven inactive.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology
Aplysia / chemistry*
Diterpenes / chemistry*
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Drug Screening Assays, Antitumor
Greece
Humans
Hydrocarbons, Brominated / chemistry*
Hydrocarbons, Brominated / isolation & purification*
Hydrocarbons, Brominated / pharmacology
Molecular Structure

Substances

Antineoplastic Agents
Diterpenes
Hydrocarbons, Brominated
luzodiol