Eur J Biochem. 1985 Apr 1;148(1):1-5.

Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities.

Galanos C, Lüderitz O, Rietschel ET, Westphal O, Brade H, Brade L, Freudenberg M, Schade U, Imoto M, Yoshimura H, et al.

Abstract

The recently chemically synthesized Escherichia coli lipid A and the natural free lipid A of E. coli were compared with respect to their endotoxic activities in the following test systems: lethal toxicity, pyrogenicity, local Shwartzman reactivity, Limulus amoebocyte lysate gelation capacity, tumour necrotizing activity, B cell mitogenicity, induction of prostaglandin synthesis in macrophages, and antigenic specificity. It was found that synthetic and natural free lipid A exhibit identical activities and are indistinguishable in all tests.

PMID:: 2579812; [PubMed - indexed for MEDLINE]

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Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities.

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