Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study

Hong Meng; Gang Liu; Jianlong Zhai; Yuzhi Zhen; Qingzhen Zhao; Mingqi Zheng; Guoping Ma; Le Wang; Li Tian; Lishuang Ji; Linan Duan; Lizhuo Li; Kunshen Liu; Chao Liu

doi:10.3899/jrheum.141037

Prednisone in Uric Acid Lowering in Symptomatic Heart Failure Patients with Hyperuricemia -- The PUSH-PATH3 Study

J Rheumatol. 2015 May;42(5):866-9. doi: 10.3899/jrheum.141037. Epub 2015 Mar 15.

Authors

Hong Meng¹, Gang Liu¹, Jianlong Zhai¹, Yuzhi Zhen¹, Qingzhen Zhao¹, Mingqi Zheng¹, Guoping Ma¹, Le Wang¹, Li Tian¹, Lishuang Ji¹, Linan Duan¹, Lizhuo Li¹, Kunshen Liu¹, Chao Liu²

Affiliations

¹ From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University.
² From the Heart Center, The First Hospital of Hebei Medical University, Shijiazhuang, China.H. Meng, MD; G. Liu, MD, J. Zhai, MD; Y. Zhen, MD; Q. Zhao, MD; M. Zheng, MD; G. Ma, MD; L. Wang, MD; L. Tian, MD; L. Ji, MD; L. Duan, MD; L. Li, MD; K. Liu, MD; C. Liu, MD, The First Hospital of Hebei Medical University. dr.liuchao@gmail.com ksliud@sohu.com.

PMID: 25774058
DOI: 10.3899/jrheum.141037

Abstract

Objective: To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia.

Methods: Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl).

Results: Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < 0.01). These favorable effects were associated with a remarkable increase in urine output, improvement in renal function, and improvement in clinical status.

Conclusion: Prednisone can be used safely in symptomatic HF patients with hyperuricemia.

Keywords: HEART FAILURE; HYPERURICEMIA; PREDNISONE; RENAL FUNCTION.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Creatinine / blood
Female
Gout Suppressants / adverse effects
Gout Suppressants / therapeutic use*
Heart Failure / complications*
Humans
Hyperuricemia / complications
Hyperuricemia / drug therapy*
Male
Middle Aged
Prednisone / adverse effects
Prednisone / therapeutic use*
Treatment Outcome
Uric Acid / blood

Substances

Gout Suppressants
Uric Acid
Creatinine
Prednisone