Genome. 1989;31(2):745-56.

Organization of human class I homeobox genes.

Boncinelli E, Acampora D, Pannese M, D'Esposito M, Somma R, Gaudino G, Stornaiuolo A, Cafiero M, Faiella A, Simeone A.

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International Institute of Genetics and Biophysics, Consiglio Nazionale delle Richerche, Naples, Italy.

Abstract

We report the genomic organization of 20 human class I homeoboxes and the predicted primary sequence of the encoded homeodomains. These homeoboxes are clustered in four complex HOX loci on chromosomes 2, 7, 12, and 17. The homeoboxes of one HOX locus can be aligned to the homeoboxes of the other HOX loci so that corresponding homeodomains in all loci can share the maximal peptide sequence identity. This correspondence of individual homeoboxes in different chromosomal loci suggests the hypothesis of large-scale duplications of a single complex locus. The existence of an ancestral complex locus might have predated the divergence of vertebrates and invertebrates.

PMID:: 2576652; [PubMed - indexed for MEDLINE]

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Organization of human homeobox genes. [Hum Reprod. 1988]
Organization of human homeobox genes.
Boncinelli E, Somma R, Acampora D, Pannese M, D'Esposito M, Faiella A, Simeone A. Hum Reprod. 1988 Oct; 3(7):880-6.
The human HOX gene family. [Nucleic Acids Res. 1989]
The human HOX gene family.
Acampora D, D'Esposito M, Faiella A, Pannese M, Migliaccio E, Morelli F, Stornaiuolo A, Nigro V, Simeone A, Boncinelli E. Nucleic Acids Res. 1989 Dec 25; 17(24):10385-402.
At least three human homeoboxes on chromosome 12 belong to the same transcription unit. [Nucleic Acids Res. 1988]
At least three human homeoboxes on chromosome 12 belong to the same transcription unit.
Simeone A, Pannese M, Acampora D, D'Esposito M, Boncinelli E. Nucleic Acids Res. 1988 Jun 24; 16(12):5379-90.
Review Homeobox genes in the developing central nervous system. [Ann Genet. 1993]
Review Homeobox genes in the developing central nervous system.
Boncinelli E, Simeone A, Acampora D, Gulisano M. Ann Genet. 1993; 36(1):30-7.
Review Homeoboxes in sea anemones and other nonbilaterian animals: implications for the evolution of the Hox cluster and the zootype. [Curr Top Dev Biol. 1998]
Review Homeoboxes in sea anemones and other nonbilaterian animals: implications for the evolution of the Hox cluster and the zootype.
Finnerty JR. Curr Top Dev Biol. 1998; 40:211-54.

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Cited by 4 PubMed Central articles

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia. [Mol Cell Biol. 1997]
Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia.
Thorsteinsdottir U, Sauvageau G, Hough MR, Dragowska W, Lansdorp PM, Lawrence HJ, Largman C, Humphries RK. Mol Cell Biol. 1997 Jan; 17(1):495-505.
Homeobox genes are expressed in the retina and brain of adult goldfish. [Proc Natl Acad Sci U S A. 1993]
Homeobox genes are expressed in the retina and brain of adult goldfish.
Levine EM, Schechter N. Proc Natl Acad Sci U S A. 1993 Apr 1; 90(7):2729-33.
The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos. [Nucleic Acids Res. 1991]
The expression of murine Hox-2 genes is dependent on the differentiation pathway and displays a collinear sensitivity to retinoic acid in F9 cells and Xenopus embryos.
Papalopulu N, Lovell-Badge R, Krumlauf R. Nucleic Acids Res. 1991 Oct 25; 19(20):5497-506.

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