Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits

P Popoli; M G Caporali; A Scotti de Carolis

doi:10.1016/0014-2999(89)90523-2

Effects of SCH 23390 on thyrotropin-releasing hormone-induced behaviour in rabbits

Eur J Pharmacol. 1989 Dec 7;173(2-3):211-3. doi: 10.1016/0014-2999(89)90523-2.

Authors

P Popoli¹, M G Caporali, A Scotti de Carolis

Affiliation

¹ Department of Pharmacology, Istituto Superiore di Sanitù, Rome, Italy.

PMID: 2576229
DOI: 10.1016/0014-2999(89)90523-2

Abstract

The influence of the dopamine D-1 receptor antagonist, SCH 23390, on thyrotropin-releasing hormone (TRH)-induced behaviour was assessed in adult male rabbits. SCH 23390 prevented the effects of TRH (100 micrograms i.c.v.), starting at a very low dose (0.01 mg/kg i.v.). This finding seems to indicate that dopamine D-1 receptors are involved in TRH-induced behaviour.

MeSH terms

Animals
Antipsychotic Agents / adverse effects
Antipsychotic Agents / pharmacology*
Behavior, Animal / drug effects*
Benzazepines / adverse effects
Benzazepines / pharmacology*
Injections, Intraventricular
Male
Rabbits
Thyrotropin-Releasing Hormone / administration & dosage
Thyrotropin-Releasing Hormone / pharmacology*

Substances

Antipsychotic Agents
Benzazepines
Thyrotropin-Releasing Hormone