CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?

Katarina Radulovic; Jan Hendrik Niess

doi:10.1155/2015/497056

CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?

J Immunol Res. 2015:2015:497056. doi: 10.1155/2015/497056. Epub 2015 Feb 22.

Authors

Katarina Radulovic¹, Jan Hendrik Niess²

Affiliations

¹ U1019, Team 7, Institut National de la Santé et de la Recherche Médicale (INSERM), 1 rue du Professeur Calmette, 59019 Lille, France ; Center for Infection and Immunity of Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, 59019 Lille, France.
² Department of Visceral Surgery and Medicine, Inselspital, Freiburgstraße, 3010 Bern, Switzerland.

Abstract

CD69 has been identified as an early activation marker of lymphocytes. However, recent work has indicated that CD69 plays an essential role for the regulation of inflammatory processes. Particularly, CD69 is highly expressed by lymphocytes at mucosal sites being constantly exposed to the intestinal microflora (one of the nature's most complex and most densely populated microbial habitats) and food antigens, while only a small number of circulating leukocytes express this molecule. In this review we will discuss the role of CD69 in mucosal tissue and consider CD69 as a potential target for the development of novel treatments of intestinal inflammation.

Publication types

Review

MeSH terms

Animals
Antigens, CD / chemistry
Antigens, CD / genetics
Antigens, CD / metabolism*
Antigens, Differentiation, T-Lymphocyte / chemistry
Antigens, Differentiation, T-Lymphocyte / genetics
Antigens, Differentiation, T-Lymphocyte / metabolism*
Biomarkers
Cell Differentiation / genetics
Cell Differentiation / immunology
Cell Movement / genetics
Cell Movement / immunology
Enteritis / drug therapy
Enteritis / genetics
Enteritis / immunology
Enteritis / metabolism*
Gastrointestinal Microbiome / immunology
Gene Expression Regulation
Humans
Immunologic Memory / genetics
Immunomodulation*
Inflammatory Bowel Diseases / drug therapy
Inflammatory Bowel Diseases / genetics
Inflammatory Bowel Diseases / immunology
Inflammatory Bowel Diseases / metabolism
Intestinal Mucosa / immunology
Intestinal Mucosa / metabolism
Intestinal Mucosa / microbiology
Lectins, C-Type / chemistry
Lectins, C-Type / genetics
Lectins, C-Type / metabolism*
Lymphocyte Activation / genetics
Lymphocyte Activation / immunology
Molecular Targeted Therapy
Signal Transduction
T-Lymphocyte Subsets / cytology
T-Lymphocyte Subsets / immunology
T-Lymphocyte Subsets / metabolism

Substances

Antigens, CD
Antigens, Differentiation, T-Lymphocyte
Biomarkers
CD69 antigen
Lectins, C-Type