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    Genomics. 1989 Oct;5(3):646-8.

    Linkage of the mouse LDL receptor gene on chromosome 9.

    Frank SL, Taylor BA, Lusis AJ.

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    Department of Microbiology, University of California, Los Angeles 90024.

    Abstract

    We identified restriction fragment length variants of the mouse low-density lipoprotein receptor gene and used these to map the gene, designated Ldlr, to the proximal region of chromosome 9. An interspecific backcross between strains MEV and CAST/Ei yielded the following gene order and distances in centimorgans: Ldlr-18.8 +/- 5.6-Apoa-4-7.3 +/- 3.5-Mpi-1-10.2 +/- 3.9-Emv-3 or dilute. Analysis of recombinant inbred strains also indicated that Ldlr is tightly linked to a previously unmapped retroviral marker, Xmmv-67.

    PMID:
    2575592
    [PubMed - indexed for MEDLINE]

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