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Lancet. 1989 Dec 2;2(8675):1319-21.

Close linkage of hypervariable marker DXS255 to disease locus of Wiskott-Aldrich syndrome.

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  • 1Unité 132 INSERM, Hôpital des Enfants Malades, Paris.


Linkage analyses in 5 families with Wiskott-Aldrich syndrome show that a novel hypervariable locus, DXS255, is very closely linked to the disease gene on the proximal short arm of the X chromosome. DXS255, with a maximum lod score of 5.42 at theta = 0.00 (90% confidence interval 0.00, 0.10) and heterozygosity of over 90%, is likely to be the closest available marker to the Wiskott-Aldrich gene and to be helpful in genetic counselling of affected families.

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