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1: Am J Hum Genet. 1989 Dec;45(6):883-8.Click here to read Links

Physical linkage of a GABAA receptor subunit gene to the DXS374 locus in human Xq28.

Bell MV, Bloomfield J, McKinley M, Patterson MN, Darlison MG, Barnard EA, Davies KE.

Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, England.

We report the physical linkage of the gene encoding one of the subunits of the GABAA receptor (GABRA3) to the polymorphic locus DXS374 on the human X chromosome at Xq28. X-linked manic depression and other psychiatric disorders have been mapped to this region, and thus GABRA3 is a potential candidate gene for these disorders. DXS374--and therefore GABRA3--lies distal to the fragile X locus at a recombination fraction of approximately .15.

PMID: 2574000 [PubMed - indexed for MEDLINE]

PMCID: PMC1683479