Tumor biology: with a little help from my dying friends

Kirsten Lauber; Martin Herrmann

doi:10.1016/j.cub.2015.01.040

Tumor biology: with a little help from my dying friends

Curr Biol. 2015 Mar 2;25(5):R198-201. doi: 10.1016/j.cub.2015.01.040.

Authors

Kirsten Lauber¹, Martin Herrmann²

Affiliations

¹ Clinic for Radiotherapy and Radiation Oncology, Ludwig-Maximilians-University Munich, Germany. Electronic address: kirsten.lauber@med.uni-muenchen.de.
² Department of Internal Medicine 3, Friedrich-Alexander-University Erlangen-Nuremberg, Germany.

PMID: 25734269
DOI: 10.1016/j.cub.2015.01.040

Abstract

Apoptosis is an essential form of cell death underlying daily tissue regeneration. In tumor biology, apoptosis resistance is a well-established hallmark of cancer that is targeted by therapeutic approaches. A new study assigns a hitherto-underestimated function to this 'deadly friend': apoptotic cells promote tumor growth, accumulation of tumor-associated macrophages, and angiogenesis.

Publication types

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MeSH terms

Apoptosis / physiology*
Gene Expression Regulation, Neoplastic / physiology*
Humans
Lymphoma, B-Cell / physiopathology*
Phagocytes / physiology*
Signal Transduction / physiology*
Tumor Microenvironment / physiology*