Lancet. 1989 Nov 18;2(8673):1176-8.

Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study.

Garland CF, Comstock GW, Garland FC, Helsing KJ, Shaw EK, Gorham ED.

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Department of Community and Family Medicine, School of Medicine, University of California, San Diego, La Jolla.

Abstract

Blood samples taken in 1974 in Washington County, Maryland, from 25 620 volunteers were used to investigate the relation of serum 25-hydroxyvitamin D (25-OHD) with subsequent risk of getting colon cancer. 34 cases of colon cancer diagnosed between August, 1975, and January, 1983, were matched to 67 controls by age, race, sex, and month blood was taken. Risk of colon cancer was reduced by 75% in the third quintile (27-32 ng/ml) and by 80% in the fourth quintile (33-41 ng/ml) of serum 25-OHD. Risk of getting colon cancer decreased three-fold in people with a serum 25-OHD concentration of 20 ng/ml or more. The results are consistent with a protective effect of serum 25-OHD on colon cancer.

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Lancet. 1990 Jan 13;335(8681):111-2.

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Chemical compound information

25-Hydroxyvitamin D 2

MW: 412.64 g/mol

MF: C₂₈H₄₄O₂

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Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study.

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